Hemotherapy Attending: Gulf Coast Pathology Associates at UT-Memorial Hermann Hospital, 09/2015 to present
Medical Director: Grifols Diagnostics Solutions, Inc., 12/2015 to 05/2017
Medical Director: Progenika, Inc. – CDX, 12/2015 to 12/2016
Medical Director: Molecular Pathology Section, Medical Director: Hematology Laboratory, Assoc Medical Director: Blood Donor Program, Assoc Medical Director: Transfusion Services, Gulf Coast Pathology Associates at Baylor St. Luke’s Medical Center, 01/2009 to 12/2015
Adjunct Asst. Professor: Department of Pathology Baylor College of Medicine, 01/2009 to present
Assistant Professor: Department of Pathology Baylor College of Medicine, 01/2007 to 01/2009
Board Certifications: Transfusion Medicine/Blood Banking Subspecialty American Board of Pathology, 9/3/2008
Clinical Pathology: American Board of Pathology, 11/18/2005
Fellowship:Transfusion Medicine/Blood Banking Baylor College of Medicine, 10/2005 - 12/2006 Houston, TX
Residency: Clinical Pathology Baylor College of Medicine, 2002 - 2005
M.D.: Baylor College of Medicine, 2002
Ph.D.: Baylor College of Medicine, 2000 Molecular and Human Genetics Thesis Advisor: John W. Belmont, M.D., Ph.D. “JKAP, a Novel Dual-specificity Phosphatase Necessary for Maximal JNK Activation”
B.A.: Rice University, 1991 cum laude Houston, TX Biology
07/14-present: Department of Molecular and Human Genetics, Baylor College of Medicine. Co-investigator: A genome-wide association study (GWAS) for sickle cell responder genes.
01/09-06/14: Texas Heart Institute (THI), St. Luke's Episcopal Hospital. Principal investigator: A genome-wide association study (GWAS) for sickle cell responder genes.
01/07-01/09: Center for Cell & Gene Therapy (CAGT), Baylor College of Medicine. Mentor: Margaret A. Goodell, Ph.D. Junior investigator: Agtr1 and erythroid development; Zfp105 and NK cell development.
07-08/2005: Center for Cell & Gene Therapy (CAGT), Baylor College of Medicine. Advisor: Margaret A. Goodell, Ph.D. Clinical Postdoctoral Fellow: Expression profiling of hematopoietic lineages.
1995-2000: Department of Molecular and Human Genetics, Baylor College of Medicine. Advisor: John W. Belmont, M.D., Ph.D. Graduate Student: Novel genes in mammalian hematopoietic development.
1994-95: Department of Molecular and Human Genetics, Baylor College of Medicine. Advisor: Vicky Lundblad, Ph.D. Graduate Student: Homologs of yeast Saccharomyces cerevisiae telomere maintenance genes.
1991-92 : Thomas J. Watson Fellowship (independent international research and travel), Endangered Parrot Species: Field Research & Protection: Indonesia, the Caribbean, Australia.
1989-91: Biochemistry Department, Rice University. Advisor: Michael C. Gustin, Ph.D. Research Assistant: Molecular genetics of ion transporters in yeast S. cerevisiae.
1989-90: Ford Foundation Undergraduate Honors Research Program, Rice University. Advisor: Michael C. Gustin, Ph.D. Undergraduate Research Student: Complementation mapping of ion sensitivity genes in yeast S. cerevisiae.
2004: Patent No.: US 7,195,902 B2, Co-inventor PHOSPHATASES WHICH ACTIVATE MAP KINASE PATHWAYS
Hanchard NA, Moulds JM, Belmont JW, Chen AJ. A genome-wide screen for large-effect alloimmunization susceptibility loci among red blood cell transfusion recipients with sickle cell disease. Transfus Med Hemother. 2014 Nov;41(6):453-461.
Li JP, Yang CY, Chuang HC, Lan JL, Chen DY, Chen YM, Wang X, Chen AJ, Belmont JW, Tan TH. The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Nat Commun. 2014 Apr 9;5:3618.
Youngblood SC, Deng Y, Chen A, Collard CD. Perioperative Therapeutic Plasmapheresis. Anesthesiology. 2013 Mar;118(3):722-8.
Bracey AW, Reyes MA, Chen AJ, Bayat M, Allison PM. How do we manage patients treated with antithrombotic therapy in the perioperative interval. Transfusion. 2011 Oct;51(10):2066-77.
Boles NC, Peddibhotla S, Chen AJ, Goodell MA, Rosen JM. Chk1 Haploinsufficiency Results in Anemia and Defective Erythropoiesis. PLoS One. 2010 Jan 5;5(1):e8581.
Chen A, Teruya J. Global hemostasis testing thromboelastography: old technology, new applications. Clin Lab Med. 2009 Jun;29(2):391-407.
Chen AJ, Zhong L, Boles NC, Goodell MA. The Angiotensin II Receptor, Type I is Differentially Expressed in the Erythroid Progenitor and is Necessary for Full Erythropoietic Potential. Manuscript in preparation.
Chambers SM, Boles NC, Lin KY, Tierney MP, Bowman TV, Bradfute SB, Chen AJ, Merchant AA, Sirin O, Weksberg DC, Merchant MG, Fisk CJ, Shaw CA, Goodell MA. Hematopoietic Fingerprints: An Expression Database of Stem Cells and Their Progeny. Cell Stem Cell. 2007 Nov 15; 1(5):578-591.
James AJ, Bender MM, Chen AJ, Bayer-Garner IB, Hsu S. Tender nodules on the extremities. Dermatology Online Journal 2003 Dec;9(5):20.
Chen AJ, Zhou G, Juan T, Colicos SM, Cannon JP, Cabriera-Hansen M, Meyer CF, Jurecic R, Copeland NG, Gilbert DJ, Jenkins NA, Fletcher F, Tan TH, and Belmont JW. The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway. J Biol Chem 2002 Sep 27; 277(39): 36592-601.
Presentations & Posters
2016 SCABB Annual Meeting: How Do Institutions Integrate Blood Group Genotyping?
2015 CBBS/SCABB Joint Meeting: A Genome-Wide Screen for Large-Effect Alloimmunization Susceptibility Loci among Red Blood Cell Transfusion Recipients with Sickle Cell Disease
2015 CBBS/SCABB Joint Meeting: The Hospital Blood Bank and the Community
2014 SCABB Annual Meeting: Double Lung Transplantation in a Patient with Anti-U: Lessons Learned
2013 ASCLS Annual Meeting: Iron for Blood Donors
2013 SCABB Annual Meeting: Who's to Blame?: Hemolysis with Both a Warm and Cold Autoantibody.
2012 NCABB 40th Annual Meeting: Who's to Blame?: Hemolysis with Both a Warm and Cold Autoantibody.
2012 SCABB Annual Meeting: Chilling with a Cold: How We Handled a Clinically Significant Cold on Cardiopulmonary Bypass.
2011 AABB Annual Meeting: Fatal Hemolysis due to an Anti-Pr.
2011 AABB Annual Meeting, Poster Session, Abstract SP328: A Genome-wide Screen for Major Alloimmunization Susceptibility Loci in Sickle Cell Disease
2010 AABB Annual Meeting: Fatal Hemolysis due to an Anti-Pr.
2010 SCABB Annual Meeting: IRL Workshop
2010 AABB Annual Meeting: Clinical Pathology Consults: Practice at SLEH
2005 American Society of Hematology 47th Annual Meeting, Poster Session, Abstract 1741: Lineage Fingerprints: The Transcriptome of the Hematopoietic System (co-author).
2003 Texas Society of Pathologists Annual Meeting, Poster Session: Diagnostic Considerations in a Case of Systemic Fungal Disease in an African American.
2000 Keystone Symposium, Signaling 2000, Poster Session: Intracellular Signal Pathways: Selective Activation of the JNK Pathway by a Novel Dual-Specificity Phosphatase.
1999 Baylor College of Medicine M.D./Ph.D. Symposium: Selective Activation of the JNK Pathway by a Novel Dual-specificity Phosphatase.
1997 Baylor College of Medicine Molecular and Human Genetics Retreat: Expression Analysis for Hematopoietic Genes.
Grants & Scholarships
2008-09: Gulf Coast Regional Blood Center Research Grant. A Genome-wide Association Study (GWAS) for Sickle Cell Responder Genes
2007-09: Molecular Medicine Scholars Program Training Grant, Baylor College of Medicine, Agtr1a and the Erythroid Progenitor
2007-08: Gulf Coast Regional Blood Center Research Grant, Agtr1a and Erythropoiesis
1996-97: Molecular and Human Genetics Departmental Training Grant, Baylor College of Medicine
1995-96: National Eye Institute Training Grant, Baylor College of Medicine
1994-95: Huffington Center on Aging Training Grant, Baylor College of Medicine
1987-91: Mary Gibbs Jones Scholarship, Rice University
1987-88: Max Roy Scholarship, Rice University
Lectures & Teaching
2009-present: Issues in Transfusion Medicine. A Comprehensive Board Review in Hematology and Medical Oncology, MD Anderson Cancer Center, Houston, TX
2015: Clinical Applications in Blood Group Genotyping and Molecular Case Studies Grifols Transfusion Science Educational Course (TSEC)
2013: Physician presenter, How Innovation Drives the Future of Healthcare. St. Luke's Leaders in Healthcare Event 2013
2008-2010: Therapeutic Apheresis. Clinical Pathology Resident Didactic Lecture Series, Baylor College of Medicine
2004-06: Transfusion Medicine/Blood Bank. Physician Assistant Clinical Lab Medicine Lecture Series, Baylor College of Medicine
2003: Medical Student Pathology Module Teaching Assistant, Baylor College of Medicine
1990-91: Introductory High School Biology, Rice University Tutoring Service
1990: Undergraduate Teaching Assistant, Genetics, Rice University
1989-90: Undergraduate Teaching Assistant, Introductory Biology, Rice University
Honors and Awards
2015: Baylor St. Luke’s Medical Center Physician-Nurse Collegiality Award
2007: Center for Cell and Gene Therapy Faculty Teaching Award
199: Lovett College Senior Service Award, Rice University
1987-90: President’s Honor Roll, all semesters, Rice University
1988-8: Outstanding College Students of America
1987-88: National Dean’s List
2010-present: Texas Society of Pathologists
2009-present: South Central Association of Blood Banks
2009-present: Association for Molecular Pathology
2008-present: American Association of Blood Banks
2007-present: Harris County Medical Association & Texas Medical Association
2002-present: Houston Society of Clinical Pathologists
2002-2011: College of American Pathologists
2002-2009: American Society of Clinical Pathologists