Appointments/Employment

Hemotherapy Attending: Gulf Coast Pathology Associates at UT-Memorial Hermann Hospital, 09/2015 to present

Medical Director: Grifols Diagnostics Solutions, Inc., 12/2015 to present

Medical Director: Progenika, Inc. – CDX, 12/2015 to present

Medical Director: Molecular Pathology Section

Medical Director: Hematology Laboratory

Assoc Medical Director: Blood Donor Program

Assoc Medical Director: Transfusion Services, Gulf Coast Pathology Associates at Baylor St. Luke’s Medical Center, 01/2009 to 12/2015

Adjunct Asst. Professor: Department of Pathology Baylor College of Medicine, 01/2009 to present

Assistant Professor: Department of Pathology Baylor College of Medicine, 01/2007 to 01/2009

Education

Board Certifications: Transfusion Medicine/Blood Banking Subspecialty American Board of Pathology, 9/3/2008

Clinical Pathology: American Board of Pathology, 11/18/2005

Fellowship:Transfusion Medicine/Blood Banking Baylor College of Medicine, 10/2005 - 12/2006 Houston, TX

Residency: Clinical Pathology Baylor College of Medicine, 2002 - 2005    

M.D.:  Baylor College of Medicine, 2002

Ph.D.:  Baylor College of Medicine, 2000 Molecular and Human Genetics Thesis Advisor: John W. Belmont, M.D., Ph.D. “JKAP, a Novel Dual-specificity Phosphatase Necessary for Maximal JNK Activation”

B.A.: Rice University, 1991 cum laude Houston, TX Biology

Research Experience

07/14-present: Department of Molecular and Human Genetics, Baylor College of Medicine. Co-investigator: A genome-wide association study (GWAS) for sickle cell responder genes.

01/09-06/14:  Texas Heart Institute (THI), St. Luke's Episcopal Hospital. Principal investigator: A genome-wide association study (GWAS) for sickle cell responder genes.

01/07-01/09: Center for Cell & Gene Therapy (CAGT), Baylor College of Medicine. Mentor: Margaret A. Goodell, Ph.D.   Junior investigator: Agtr1 and erythroid development; Zfp105 and NK cell development.

07-08/2005: Center for Cell & Gene Therapy (CAGT), Baylor College of Medicine. Advisor: Margaret A. Goodell, Ph.D. Clinical Postdoctoral Fellow: Expression profiling of hematopoietic lineages.  

1995-2000: Department of Molecular and Human Genetics, Baylor College of Medicine. Advisor: John W. Belmont, M.D., Ph.D. Graduate Student: Novel genes in mammalian hematopoietic development.

1994-95: Department of Molecular and Human Genetics, Baylor College of Medicine. Advisor: Vicky Lundblad, Ph.D. Graduate Student: Homologs of yeast Saccharomyces cerevisiae telomere maintenance genes.

1991-92 : Thomas J. Watson Fellowship (independent international research and travel), Endangered Parrot Species: Field Research & Protection: Indonesia, the Caribbean, Australia.

1989-91:  Biochemistry Department, Rice University. Advisor: Michael C. Gustin, Ph.D. Research Assistant: Molecular genetics of ion transporters in yeast S. cerevisiae.

1989-90: Ford Foundation Undergraduate Honors Research Program, Rice University. Advisor: Michael C. Gustin, Ph.D. Undergraduate Research Student: Complementation mapping of ion sensitivity genes in yeast S. cerevisiae.

Patents

2004: Patent No.: US 7,195,902 B2, Co-inventor PHOSPHATASES WHICH ACTIVATE MAP KINASE PATHWAYS

Publications

Hanchard NA, Moulds JM, Belmont JW, Chen AJ. A genome-wide screen for large-effect alloimmunization susceptibility loci among red blood cell transfusion recipients with sickle cell disease. Transfus Med Hemother. 2014 Nov;41(6):453-461.

Li JP, Yang CY, Chuang HC, Lan JL, Chen DY, Chen YM, Wang X, Chen AJ, Belmont JW, Tan TH. The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Nat Commun. 2014 Apr 9;5:3618.

Youngblood SC, Deng Y, Chen A, Collard CD. Perioperative Therapeutic Plasmapheresis. Anesthesiology. 2013 Mar;118(3):722-8.

Bracey AW, Reyes MA, Chen AJ, Bayat M, Allison PM. How do we manage patients treated with antithrombotic therapy in the perioperative interval. Transfusion. 2011 Oct;51(10):2066-77.

Boles NC, Peddibhotla S, Chen AJ, Goodell MA, Rosen JM. Chk1 Haploinsufficiency Results in Anemia and Defective Erythropoiesis. PLoS One. 2010 Jan 5;5(1):e8581.

Chen A, Teruya J. Global hemostasis testing thromboelastography: old technology, new applications. Clin Lab Med. 2009 Jun;29(2):391-407.

 Chen AJ, Zhong L, Boles NC, Goodell MA. The Angiotensin II Receptor, Type I is Differentially Expressed in the Erythroid Progenitor and is Necessary for Full Erythropoietic Potential. Manuscript in preparation.

Chambers SM, Boles NC, Lin KY, Tierney MP, Bowman TV, Bradfute SB, Chen AJ, Merchant AA, Sirin O, Weksberg DC, Merchant MG, Fisk CJ, Shaw CA, Goodell MA. Hematopoietic Fingerprints: An Expression Database of Stem Cells and Their Progeny. Cell Stem Cell. 2007 Nov 15; 1(5):578-591.

James AJ, Bender MM, Chen AJ, Bayer-Garner IB, Hsu S. Tender nodules on the extremities. Dermatology Online Journal 2003 Dec;9(5):20.

Chen AJ, Zhou G, Juan T, Colicos SM, Cannon JP, Cabriera-Hansen M, Meyer CF, Jurecic R, Copeland NG, Gilbert DJ, Jenkins NA, Fletcher F, Tan TH, and Belmont JW. The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway. J Biol Chem 2002 Sep 27; 277(39): 36592-601.

Presentations & Posters

2016: How Do Institutions Integrate Blood Group Genotyping?

2016 SCABBAnnual Meeting

2015: A Genome-Wide Screen for Large-Effect Alloimmunization Susceptibility Loci among Red Blood Cell Transfusion Recipients with Sickle Cell Disease

2015 CBBS/SCABB Joint Meeting

2015: The Hospital Blood Bank and the Community

2015 CBBS/SCABB Joint Meeting

2014: Double Lung Transplantation in a Patient with Anti-U: Lessons Learned 

2014 SCABB Annual Meeting

2013: Iron for Blood Donors

2013: ASCLS Annual Meeting

2013: Who's to Blame?: Hemolysis with Both a Warm and Cold Autoantibody. 

2013 SCABB Annual Meeting

2012: Who's to Blame?: Hemolysis with Both a Warm and Cold Autoantibody.

2012: NCABB 40th Annual Meeting

2012: Chilling with a Cold: How We Handled a Clinically Significant Cold on Cardiopulmonary Bypass.

2012 SCABB Annual Meeting

2011: Fatal Hemolysis due to an Anti-Pr.

2011 AABB Annual Meeting;

2011: A Genome-wide Screen for Major Alloimmunization Susceptibility Loci in Sickle Cell Disease

2011 AABB Annual Meeting, Poster Session, Abstract SP328

2010: Fatal Hemolysis due to an Anti-Pr.

2010: AABB Annual Meeting

2010: IRL Workshop, SCABB Annual Meeting

2010: Clinical Pathology Consults: Practice at SLEH

2010: AABB Annual Meeting

2005 : Lineage Fingerprints: The Transcriptome of the Hematopoietic System (co-author).  American Society of Hematology 47th Annual Meeting, Poster Session, Abstract 1741

2003: Diagnostic Considerations in a Case of Systemic Fungal Disease in an African American. Texas Society of Pathologists Annual Meeting, Poster Session

2000: Selective Activation of the JNK Pathway by a Novel Dual-Specificity Phosphatase. Keystone Symposium, Signaling 2000, Poster Session: Intracellular Signal Pathways

1999: Selective Activation of the JNK Pathway by a Novel Dual-specificity Phosphatase. Baylor College of Medicine M.D./Ph.D. Symposium

1997: Expression Analysis for Hematopoietic Genes. Baylor College of Medicine Molecular and Human Genetics Retreat

Grants & Scholarships

2008-09: Gulf Coast Regional Blood Center Research Grant. A Genome-wide Association Study (GWAS) for Sickle Cell Responder Genes

2007-09: Molecular Medicine Scholars Program Training Grant, Baylor College of Medicine, Agtr1a and the Erythroid Progenitor

2007-08: Gulf Coast Regional Blood Center Research Grant, Agtr1a and Erythropoiesis

1996-97: Molecular and Human Genetics Departmental Training Grant, Baylor College of Medicine

1995-96: National Eye Institute Training Grant, Baylor College of Medicine

1994-95: Huffington Center on Aging Training Grant, Baylor College of Medicine

1987-91: Mary Gibbs Jones Scholarship, Rice University

1987-88: Max Roy Scholarship, Rice University

Lectures & Teaching

2009-present: Issues in Transfusion Medicine. A Comprehensive Board Review in Hematology and Medical Oncology, MD Anderson Cancer Center, Houston, TX

2015: Clinical Applications in Blood Group Genotyping and Molecular Case Studies Grifols Transfusion Science Educational Course (TSEC)

2013: Physician presenter, How Innovation Drives the Future of Healthcare. St. Luke's Leaders in Healthcare Event 2013

2008-2010: Therapeutic Apheresis. Clinical Pathology Resident Didactic Lecture Series, Baylor College of Medicine

2004-06: Transfusion Medicine/Blood Bank. Physician Assistant Clinical Lab Medicine Lecture Series, Baylor College of Medicine

2003: Medical Student Pathology Module Teaching Assistant, Baylor College of Medicine

1990-91: Introductory High School Biology, Rice University Tutoring Service

1990: Undergraduate Teaching Assistant, Genetics, Rice University

1989-90: Undergraduate Teaching Assistant, Introductory Biology, Rice University

Honors and Awards

2015: Baylor St. Luke’s Medical Center Physician-Nurse Collegiality Award

2007: Center for Cell and Gene Therapy Faculty Teaching Award

199: Lovett College Senior Service Award, Rice University

1987-90: President’s Honor Roll, all semesters, Rice University

1988-8: Outstanding College Students of America

1987-88: National Dean’s List

Professional Memberships

2010-present: Texas Society of Pathologists

2009-present: South Central Association of Blood Banks

2009-present: Association for Molecular Pathology

2008-present: American Association of Blood Banks

2007-present: Harris County Medical Association & Texas Medical Association

2002-present: Houston Society of Clinical Pathologists

2002-2011: College of American Pathologists

2002-2009: American Society of Clinical Pathologists