Appointments/Employment

Chairman/Professor, Pathology & Immunology, Baylor College of Medicine - Houston, TX, US

Education

Degree-Granting Education

MD: University Medical School of Debrecen, Debrecen, Hungary, M.D., 09/1977

PhD: University Medical School of Debrecen, Debrecen, Hungary, and Hungarian Academy of Sciences, Budapest, Hungary, Ph.D., 03/1997, Medical Sciences


Postgraduate Training

09/1977 - 04/1981 - Residency in Anatomic Pathology, University Medical School of Debrecen, Hungary

01/1989 - 06/1989 - Postdoctoral Fellowship, US-Hungarian Cancer Agreement, Laboratory of Molecular Immunoregulation, Biological Response Modifiers Program, NCI, NIH, Frederick, MD

8/1989 - 12/1990 - Postdoctoral Fellowship, Department of Pharmacology, UTHSC, Houston, Texas

07/1997 - 06/2001- Resident, AP/CP, Department of Pathology and Laboratory Medicine, UT-Houston Medical School

07/2001 – 06/2002 – Fellow, Hematopathology, Department of Hematopathology, M.D. Anderson Cancer Center, Houston, Texas

Board Certification

Hungarian Board of Pathology, AP, 1981

The American Board of Pathology, AP/CP, 2001

The American Board of Pathology, Hematology, 2004

American Board of Clinical Chemistry, Molecular Diagnostics, 2009

Licensure

Texas, L6670, 8/31/2016

Experience/Service


07/2009 – present, Pathologist, Gulf Coast Pathology Associates (St. Luke's Hospital; Baylor-St. Luke's Medical Center; Kingwood Medical Center)

07/2005-07/2009, Pathologist, Austin Pathology Associates, Austin, TX

10/2003-06/2005, Assistant Professor, tenure track, Department of Hematopathology, UT M.D. Anderson Cancer Center, Houston, TX

7/2002-10/2003, Assistant Professor, tenure track, Department of Pathology, UTHSC, Houston, TX

3/1993-6/1997, Visiting Associate Research Professor, non-tenure track, Department of Pharmacology, UTHSC, Houston, TX

1/1987-2/1993, Adjunct Professor of Anatomic Pathology, tenure track, Department of Pathology, University Medical School, Debrecen, Hungary

5/1981-12/1986, Assistant Professor of Anatomic Pathology, tenure track, Department of Pathology, University Medical School, Debrecen, Hungary

Publications


Articles in Peer-Reviewed Journals

56. Loo EY, Medeiros LJ, Aladily TN, Hoehn D, Kanagal-Shamanna R, Young KH, Lin P, Bueso-Ramos CE, Manning JT Jr, Patel K, Thomazy V, Brynes RK, Goswami M, Fayad LE, Miranda RN. Classical Hodgkin lymphoma arising in the setting of iatrogenic immunodeficiency: a clinicopathologic study of 10 cases. Am J Surg Pathol. 2013 Aug;37(8):1290-7.

55.Inamdar KV, O'Brien S, Sen S, Keating M, Nguyen MH, Wang X, Fernandez M, Thomazy V, Medeiros LJ, Bueso-Ramos CE. Aurora-A kinase nuclear expression in chronic lymphocytic leukemia. Mod Pathol. 2008 Dec;21(12):1428-35.

54.Vega F, Coombes KR, Thomazy VA, Patel K, Lang W, Jones D. Tissue-specific function of lymph node fibroblastic reticulum cells. Pathobiology. 2006;73(2):71-81.

53.Lin Q, Lai R, Chirieac LR, Li C, Thomazy VA, Grammatikakis I, Rassidakis GZ, Zhang W, Fujio Y, Kunisada K, Hamilton SR, Amin HM. Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am J Pathol 167:969-980 (2005).

52. Yin CC, Medeiros LJ, Abruzzo LV, Jones D, Farhood AI, Thomazy VA. EBV-associated B-cell and T-cell post-transplant lymphoproliferative disorders following primary EBV infection in a kidney transplant recipient. Am J Clin Pathol 123:222-228 (2005).

51. Thomazy V, Vega F, Medeiros L, Davies P, Jones D. Phenotypic modulation of the stromal reticular network in normal and neoplastic lymph nodes: tissue transglutaminase reveals coordinate regulation of multiple cell types. Am J Pathol. 163:165-174 (2003).

50. Jilani I, O'Brien S, Manshuri T, Thomas DA, Thomazy VA, Imam M, Naeem S, Verstovsek S, Kantarjian H, Giles F, Keating M, Albitar M. Transient down-modulation of CD20 by rituximab in patients with chronic lymphocytic leukemia. Blood 102:3514-3520(2003).

49. Thomazy V, Rajyalakshmi L, Uthman M, Davies P, Medeiros L. Determination of cyclin D1 and CD20 mRNA levels by real-time quantitative RT-PCR from archival tissue sections of mantle cell lymphoma and other non-Hodgkin’s lymphomas. J Mol Diagn 4:201-208 (2002).

48. Uray I, Connelly J, Thomazy V, Shipley G, Vaughn W, Frazier O, Taegtmeyer H, Davies P. Left ventricular unloading alters receptor tyrosine kinase expression in the failing human heart. J Heart Lung Transplant 21: 771-782 (2002).

47. Medeiros L, Hai S, Thomazy V, Estalilla O, Romaguera J, Luthra R. Real-time RT-PCR assay for quantifying cyclin D1 mRNA in B-cell non-Hodgkin’s lymphomas. Mod Pathol 5:556-564 (2002).

46. Juneja H, Lee S, Thomazy V, Shipley G, Davies P. Acute activation of gp130 gene expression in bone marrow stromal cells by contact with myeloma-derived lymphoblastic cell line ARH77 cell membranes. J Interferon Cytokine Res. 21:157-166 (2001).

45. Thomazy V, and Davies P. Expression of tissue transglutaminase in the developing chicken limb is associated both with apoptosis and endochondral ossification. Cell Death Differentation 6:146-154 (1999).

44. Dupé V, Ghyselinck N, Thomazy V, Nagy L, Davies P, Chambon P, Mark M. Essential roles of retinoic acid signaling in interdigital apoptosis and control of BMP-7 expression in mouse autopods. Dev Biol 208:30-43 (1999).

43. Saez E, Tontonoz P, Nelson M, Alvarez J, Ming U, Baird S, Thomazy V, Evans R. Activators of the nuclear receptor PPARγ enhance colon polyp formation. Nature Med 4:1058-1061 (1998).

42. Tontonoz P, Nagy L, Alvarez J, Thomazy V, Evans R. PPAR-γ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93:1-20 (1998).

41. Kuncio G, Tsyganskaya M, Zhu J, Liu S, Nagy L, Thomazy V, Davies P, Zern M. TNF-alpha modulates expression of the tissue transglutaminase gene in liver cells. Am J Physiol 274:G240-245 (1998).

40. Kirkland J, Murthy L, Thomazy V, Hyder S, Stancel G. Phorbol ester inhibition of estrogen-induced uterine deoxyribonucleic acid synthesis. Biol. Reprod. 58:778-785 (1998).

39. Nagy L, Thomazy V, Saydak M, Stein J, Davies P. The promoter of the mouse tissue transglutaminase gene directs tissue-specific, retinoid-regulated, and apoptosis-linked expression. Cell Death Differentiation 4:534-547 (1997).

38. Standeven A, Davies P, Chandraratna R, Mader D, Johnson A, Thomazy V. Retinoid-induced epiphyseal closure in guinea pigs. Fund Applied Toxicol 34:91-98 (1996).

37. Shalinsky D, Bischoff E, Gregory M, Lamph W, Heyman R, Thomazy V, Hayes J, Davies P. Enhanced antitumor efficacy of cisplatin in combination with LGD1057 (9-cis retinoic acid) in human head and neck xenografts. Clin Cancer Res 2:511-520 (1996).

36. Nagy L, Thomazy V, Heyman R, Chandraratna R, Davies P. Retinoid-regulated expression of bcl-2 and tissue transglutaminase during differentiation and apoptosis of human myeloid leukemia (HL-60) cells. Leukemia Res 20:499-505 (1996).

35. Shalinsky D, Gregory M, Bischoff E, Gottardis M, Hayes J, Lamph W, Cooke T, Heyman R, Shirley M, Davies P and Thomazy V. Retinoid-induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts in athymic nude mice. Cancer Res 55:3183-3191 (1995).

34. Kirkland J, Thomazy V, Murthy L, Stancel G. Phorbol esters inhibit estrogen-induced uterine DNA-synthesis and increase apoptosis in uterine epithelium. Rec Progr Hormone Res 50:455-458 (1995).

33. Nagy L, Thomazy V, Shipley GL, Fesus L, Lamph W, Heyman R, Chandraratna R, Davies P. Activation of retinoid X receptors induces apoptosis in HL-60 cell lines. Mol Cell Biol 15: 3540-3551 (1995).

32. Thomazy V, Nagy A, Gal I, Nemes Z. Plexiform fibrohistiocytic tumour with novel phenotypic features. Histopathology 25:165-169 (1994).

31. Gentile V, Thomazy V, Piacentini M, Fesus L, Davies P. Expression of tissue transglutaminase in Balb-C 3T3 fibroblasts: Effects on cellular morphology and adhesion. J Cell Biol 119:463-474 (1992).

30. Tarcsa E, Kedei N, Thomazy V, Fesus L. An involucrin-like protein in hepatocytes serves as a substrate for tissue transglutaminase during apoptosis. J Biol Chem 267: 25648 – 25651 (1992).

29. Piacentini M, Ceru MP, Dini L, Di Rao M, Piredda L, Thomazy V, Davies P, Fesus L. In vivo and in vitro induction of `tissue` transglutaminase in rat hepatocytes by retinoic acid. Biochim Biophys Acta 1135:171-179 (1992).

28. Thomazy V, Fesus L. Differential expression of tissue transglutaminase in human cells. An immunohistochemical study. Cell Tissue Res 255:215-224 (1989).

27. Fesus L, Thomazy V, Autuori F, Ceru M, Tarcsa E, Piacentini M. Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action. FEBS Lett 245:150-154 (1989).

26. Ivanyi J, Kiss A, Thomazy V. Histochemical observations on bone marrow biopsies embedded in glycol methacrylate (Technovit 7100). Appl Pathol 7:116-21 (1989).

25. Nemes Z, Thomazy V. Diagnostic significance of histiocyte-related markers in malignant histiocytosis and true histiocytic lymphoma. Cancer 62:1970-1980 (1988).

24. Nemes Z, Thomazy V. Factor XIIIa and the classic histiocytic markers in malignant fibrous histiocytoma. A comparative immunohistochemical study. Human Pathol 19:822-829 (1988).

23. Miko T, Thomazy V. The calibre persistent artery of the stomach. A unifying
approach to gastric aneurysm, Dieulafoy’s lesion and submucosal arterial malformation. Human Pathol 19:914-921 (1988).

22. Miko TL, Lampe L, Thomazy V, Molnar P, Endes P. Eosinophilic endomyometritis associated with diagnostic curettage. Internatl. J Gynecol Pathol 7:162-172 (1988).

21. Fesus L, Thomazy V, Falus A. Induction and activation of tissue transglutaminase during programmed cell death. FEBS Lett 224:104-108 (1987).

20. Szappanos L, Thomazy V. Spondylolysis in osteopetrosis. J. Bone Joint Surg. (Br) 70-B:428-430 (1987).

19. Nemes Z, Adany R, Thomazy V. Selective visualization of human dendritic reticulum cells in reactive lymphoid follicles by the immunohistochemical demonstration of the subunit A of factor XIII(F-XIIIa). Virchows Arch. (Cell Pathol.) 52:453-466 (1987).

18. Ivanyi JL, Thomazy V, Kiss A, Szeifert G. Histology of CGL, CMGM, and myelofibrosis. Magyar Belorv. Arch. 40:263-269 (1987) (in Hungarian).

17. Ember I, Olah E, Balogh E, Arany I, Rady P, Matyus L, Thomazy V, Kertai P. Transplantation of chemically induced mouse leukemia into newborn F344 rats. Haematologia 19:207-217 (1986).

16. Szeifert G, Thomazy V, Nemes Z. Sarcomatoid cancer of the larynx and esophagus: An immuno¬histo¬chemical study. Magyar Onkol. 30:171-178 (1986) (in Hungarian).

15. Szeifert GT, Nemes Z, Thomazy V, Modis L. Inflammatory fibrous histiocytoma of bone. Acta Morphol. Hung. 34:95-105 (1986).

14. Ember I, Szallasi A, Arany I, Farkas T, Rady P, Matyus L, Thomazy V. Transplantation experiments with Gross’ virus leukemia in CBA/Ca mice. Magyar Onkol. 30:102-113 (1986) (in Hungarian).

13. Ember I, Arany I, Thomazy V. Follow-up of chemically induced, serially

12. Nemes Z, Thomazy V, Adany R, Muszbek L. Identification of histiocytic reticulum cells by the immuno¬histochemical demonstration of factor XIII (F-XIIIa) in human lymph nodes. J Pathol 149:121-132 (1986).

11. Ember I, Thomazy V, Matyus L. The leukemogenic effect of Haloperidol in AKC3 F1 hybrid mice. Arch Toxicol 8(S):507-508 (1985).

10. Barzo P, Molnar L, Csokonay L, Thomazy V. Extrinsic allergic alveolitis (farmer's lung) caused by thermophilic fungi in agricultural workers. Orv Hetil 126:2899-2905 (1985) (in Hungarian).

9. Pap T, Brittig F, Banlaki S, Racz I, Kovacs I, Thomazy V, Vogt U. Cumulative occurrence of Burkitt-type non-Hodgkin's malignant lymphoma in Hungary. Orv Hetil 125:573-577 (1984) (in Hungarian).

8. Nemes Z, Thomazy V, Szeifert G. Demonstration of light chain monotypia in B cell non-Hodgkin’s lymphomas using freeze-dried and formalin-fixed trypsinized paraffin sections. J. Clin.Pathol. 36:883-893 (1983).

7. Nemes Z, Thomazy V, Szeifert G. Sensitivity and specificity of immunohistological methods on freeze-dried paraffin sections. J Immunol Meth 49:53-64 (1982).

6. Ember I, Szollosi J, Thomazy V, Rady P, Kertai P. A rapid method of following the spontaneous regression of experimental leukemias. Experientia 38:1234-1235 (1982).

5. Pfliegler G, Udvardy M, Thomazy V, Vezekenyi K, Alfoldi G. Lyell syndrome in a patient with Cushing disease. Orv Hetil 122:2781-2783 (1981) (in Hungarian).

4. Ember I, Arany I, Rady P, Szollosi J, Tatar-Kiss Z, Thomazy V, Kertai P. Spontaneous regression of transplanted Gross’ leukemia in C3H/He-mg mice. Kiserletes. Orvostud. 33:101-106 (1981) (in Hungarian).

3. Nemes Z, Thomazy V, Szeifert G. Follicular centre cell lymphoma with alpha heavy chain disease. A histo¬pathological and immunohistological study. Virchows Arch. (Pathol. Anat.) 394:119-132 (1981).

2. Szombathy G, Kerepesi T, Zsonda L, Thomazy V, Karmazsin L. Primary combined immune defect in a pair of siblings. Orv Hetil 121:699-701 (1980) (in Hungarian).

1. Szokol M, Schomig A, Thomazy V, Kovacs Zs. On the lipid granularity of renomedullary interstitial cells in benign and malignant courses of renal hypertension. Exp Pathol 17:143-151 (1979).

Invited Articles

1. Miko T, Thomazy V. (1990) The caliber persistent artery of the stomach: A unifying approach to gastric aneurysm, Dieulafoy’s lesion, and submucosal arterial malformation. In: Brinkhous KM (ed) The Year Book of Pathology and Clinical Pathology, Year Book Medical Publishers, p 111.

2. Nagy L, Thomazy V, Davies P. Transglutaminases: Effector molecules in physiologic cell death. Cancer Bull. 46:136-140 (1994).

3. Nagy L, Thomazy V, Davies P. A transgenic mouse model for the study of apoptosis during limb development. Cell Death Differ. 5:126 (1998).

4. Nagy L, Thomazy V, Heyman R, Davies P. Retinoid-induced apoptosis in normal and neoplastic tissues. Cell Death Differ. 5:11-19 (1998).

5. Aeschlimann D, Thomazy V. Protein crosslinking in assembly and remodelling of extracellular matrices: the role of transglutaminases. Connective Tissue Res. 41:1-27 (2000).

Selected Abstracts (1999-2054 only)

Thomazy VA, Kantarjian HM, Imam M, Davies PJ, Aguilar C, Jilani I, Cortes J, Giles FJ, Albitar M (2004) Use of Plasma RNA for Real -Time Quantitative RT-PCR to Monitor Imatinib Therapy in Patients with Chronic Myeloid Leukemia (Meeting abstract #1099, 46th Annual Meeting of the American Society of Hematology (December 4-7, 2004, San Diego, CA, Blood 104:312a (2004)

Thomazy VA, Vega F, Medeiros LJ, Davies PJ, Jones D (2002) Tissue transglutaminase expression uncovers coordinate phenotypic regulation of several cell types in the paracortex of normal and neoplastic lymph nodes. (Meeting abstract, USCAP 91st Annual Meeting, Feb 23 – March 1, 2002, Chicago, IL). Mod Pathol 15:266A

Thomazy VA, Luthra R, Uthman MA, Davies PJA, Medeiros LJ (2001) B-cell-specific overexpression of cyclin D1 in mantle cell lymphomas as determined by real-time quantitative RT-PCR analysis of microdissected paraffin sections. (Meeting abstract, USCAP 90th Annual Meeting, March 3-9, 2001, Atlanta, GA). Mod Pathol 14:

Thomazy VA, Biddle DA , Croitoru CM, Farhood AI, Davies PJA (2000) Estrogen receptor-β expression correlates with HER2/neu expression in invasive ductal breast carcinomas as determined by real-time quantitative RT-PCR from microdissected paraffin sections. (Meeting abstract, USCAP 89th Annual Meeting, March 25-31, 2000, New Orleans, LA) Mod Pathol 13:202A

Thomazy VA, Croitoru CM, Biddle DA, Davies PJA, Farhood AI (2000) Analysis of HER2/neu overexpression in microdissected paraffin sections of invasive breast carcinoma by real-time quantitative RT-PCR. (Meeting abstract, USCAP 89th Annual Meeting, March 25-31, 2000, New Orleans, LA) Mod Pathol 13:48A

Thomazy VA, Crombie DL, Heyman RA, Davies PJA (1999) Reversal of islet atrophy and restoration of Fas ligand expression by RXR and PPARγ activators in db/db mice. (Meeting abstract, USCAP 88th Annual Meeting, March 20-26, 1999, San Francisco, CA) Mod Pathol 12:70A

Book Chapters


Adany R, Nemes Z, Thomazy V, Muszbek L. Identification of FXIII in macrophages invading lymph nodes with Hodgkin's disease. In: Muszbek L (ed) Hemostasis and Cancer, CRC Press, Boca Raton, Fla, pp. 115-123 (1987).

Fesus L, Thomazy V. Searching for the function of tissue transglutaminase: Its possible involvement in the biochemical pathway of programmed cell death. In: Zappia V, Galetti P, PortaR, Wold F (eds) Adv. Exp. Med. Biol., vol 231, ‘Advances in post-translational modification ofproteins and ageing’, Plenum Press, New York, London, pp. 119-134 (1988).

Piacentini M, Thomazy V, Tarcsa E, Farrace M, Autuori F, Fesus L. Role of tissue transglutaminase in the formation of apoptotic bodies. In: Columbano A (ed) Chemical Carcinogenesis 2. Plenum Press, New York, 461-471 (1991).

Davies P, Stein J, Chiocca E, Basilion J, Gentile V, Thomazy V, Fesus L. Retinoid-regulated expression of transglutaminases: links to the biochemistry of programmed cell death. In: Morris-Kay G (ed) ‘Retinoids in normal development and teratogenesis’ Oxford University Press, pp. 249-263 (1992).

Thomazy VA, Kantarjian HM, Imam M, Davies PJ, Aguilar C, Jilani I, Cortes J, Giles FJ, Albitar M (2004) Use of Plasma RNA for Real -Time Quantitative RT-PCR to Monitor Imatinib Therapy in Patients with Chronic Myeloid Leukemia (Meeting abstract #1099, 46th Annual Meeting of the American Society of Hematology (December 4-7, 2004, San Diego, CA, Blood 104:312a (2004)